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D-Glucuronic acid lactone

D-Glucuronic acid lactone (D-Glucurono-6,3-lactone) is an endogenous metabolite, which is a glucuronic acid derivative. D-Glucuronic acid lactone can be used as starting regents in the synthesis of 2,3,4, -tris (tert.-butyldimethysilyl) glucuronic acid trichloroethylester, requirement for the preparation of 1-O-acyl glucuronide of the anti-inflammatory agent ML-3000 (HY-B1452), synthesis of optically active glucopyranoses, synthesis of long-chain alkyl glucofuranosides. D-Glucuronic acid lactone is promising for research of reversible cerebral vasoconstriction syndrome (RCVS) [1][2][3][4].

Product Specifications

CAS Number

[32449-92-6]

Product Name Alternative

D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Drug Derivative; Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/d-glucuronic-acid-lactone.html

Concentration

10mM

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C1[C@@H](O)[C@@H](O)[C@]([C@@H](O)C=O)([H])O1

Molecular Formula

C6H8O6

Molecular Weight

176.12

Precautions

H315, H319, H335

References & Citations

[1]Florio P, et al. Rapid access to uronic acid-based mimetics of Kdn2en from D-glucurono-6,3-lactone. Carbohydr Res. 2000 Oct 6;328 (4) :445-8. |[2]Dahlhoff W V, et al. l‐Gulose or d‐gluco‐Hexodialdose from d‐Glucurono‐6, 3‐lactone by Controlled Reductions[J]. Angewandte Chemie International Edition in English, 1980, 19 (7) : 546-547.|[3]Glišin Đ, et al. D-glucurono-6, 3-lactone as an interesting compound in the synthetic chemistry of carbohydrates related targets[J]. Advanced Technologies, 2023, 12 (1) : 84-88.|[4]Hsu WH, et al. Urine metabolomics signatures in reversible cerebral vasoconstriction syndrome. Cephalalgia. 2020 Jun;40 (7) :735-747.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite

Available Sizes

Curated Selection

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