Tirbanibulin
Tirbanibulin (KX2-391) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
Product Specifications
CAS Number
897016-82-9
Product Name Alternative
KX2-391; KX-01
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Microtubule/Tubulin; Src
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kx2-391.html
Purity
99.45
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C(CC1=NC=C(C2=CC=C(OCCN3CCOCC3)C=C2)C=C1)NCC4=CC=CC=C4
Molecular Formula
C26H29N3O3
Molecular Weight
431.53
Precautions
H315, H319, H320
References & Citations
[1]Lau GM, et al. Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro. Dig Dis Sci, 2009, 54 (7), 1465-1474.|[2]Fallah-Tafti A, et al. Thiazolyl N-benzyl-substituted acetamide derivatives: synthesis, Src kinase inhibitory and anticancer activities. Eur J Med Chem, 2011, 46 (10), 4853-4858.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
BioRxiv. 2023 Dec 14.|Brain Res. 2020 Jun 1;1736:146782.|Cancer Cell. 2024 Apr 8;42 (4) :682-700.e12.|J Biol Chem. 2019 Nov 29;294 (48) :18099-18108.|J Exp Clin Cancer Res. 2025 Jul 8;44 (1) :195.|Nat Commun. 2024 Sep 9;15 (1) :7885.|University of Colorado Denver. 2024.|Harvard Medical School LINCS LIBRARY|Sci Transl Med. 2018 Jul 18;10 (450) :eaaq1093.
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