Oxomemazine
Product Specifications
UNSPSC Description
Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 μM, M2 receptor) affinity sites[1]. Oxomemazine an antihistamine and anticholinergic agent used for the study of cough treatment[2].
Target Antigen
Histamine Receptor; mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/oxomemazine.html
Smiles
CC(CN1C2=C(C=CC=C2)S(C3=CC=CC=C13)(=O)=O)CN(C)C
Molecular Weight
330.44
References & Citations
[1]S W Lee, et al.Selectivity of oxomemazine for the M1 muscarinic receptors.Arch Pharm Res. 1994 Dec;17(6):443-51.|[2]M S Siddegowda, et al.Oxomemazine hydro-chloride. Acta Crystallogr Sect E Struct Rep Online. 2011 Aug 1;67(Pt 8):o1875.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-136587/Oxomemazine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-136587/Oxomemazine-SDS-MedChemExpress.pdf
CAS Number
3689-50-7
Available Sizes
Curated Selection
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