TAME

TAME is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME is not cell permeable[1][2].

Product Specifications

CAS Number

[901-47-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

APC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tame.html

Concentration

10mM

Purity

99.51

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C=C1)S(N[C@H](C(OC)=O)CCCNC(N)=N)(=O)=O

Molecular Formula

C14H22N4O4S

Molecular Weight

342.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Zeng X, et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19;18 (4) :382-95.|[2]Zeng X, et al. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol. 2012 Feb 26;8 (4) :383-92.