Nesuparib
Nesuparib (JPI-547) is the orally active inhibitor for PARP 1/2 and Tankyrase 1/2 that inhibits tankyrases 1, tankyrases 2, and PARP 1 with IC50s of 5, 1 and 2 nM, respectively. Nesuparib exhibits antitumor activity and can be used in research of advanced solid tumor[1][2][3].
Product Specifications
CAS Number
2055357-64-5
Product Name Alternative
JPI-547/OCN-201
UNSPSC
12352005
Target
PARP; Wnt; β-catenin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nesuparib.html
Purity
99.54
Solubility
DMSO : 60 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=CN=C(N2CCN(CC2)CC3=CC(NC(C4=C5NCCC4)=O)=C5C=C3)C=C1
Molecular Formula
C23H24N6O
Molecular Weight
400.48
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PARP2; TNKS1/PARP5A; TNKS2/PARP5B
Available Sizes
Frequently Asked Questions
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