Rabbit DKK1 Antibody

<strong>Rabbit DKK1 Antibody</strong>_x000D_ <strong>Catalog number:</strong> B2013103_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 uL_x000D_ <strong>Molecular Weight or Concentration:</strong> 29 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Purified Rabbit Polyclonal Antibody_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Wall JA, Klempner SJ, Arend RC. The anti-DKK1 antibody DKN-01 as an immunomodulatory combination partner for the treatment of cancer Expert Opin Investig Drugs. 2020 Jul;29(7):639-644._x000D_ 2: Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future Lancet. 2011 Apr 9;377(9773):1276-87._x000D_ 3: Jiang H, Zhang Z, Yu Y, Chu HY, Yu S, Yao S, Zhang G, Zhang BT. Drug Discovery of DKK1 Inhibitors Front Pharmacol. 2022 Mar 9;13:847387._x000D_ 4: Klempner SJ, Bendell JC, Villaflor VM, Tenner LL, Stein SM, Rottman JB, Naik GS, Sirard CA, Kagey MH, Chaney MF, Strickler JH. Safety, Efficacy, and Biomarker Results from a Phase Ib Study of the Anti-DKK1 Antibody DKN-01 in Combination with Pembrolizumab in Advanced Esophagogastric Cancers Mol Cancer Ther. 2021 Nov;20(11):2240-2249._x000D_ 5: Wang Q, Tian J, Li X, Liu X, Zheng T, Zhao Y, Li X, Zhong H, Liu D, Zhang W, Zhang M, Li M, Zhang M. Upregulation of Endothelial DKK1 (Dickkopf 1) Promotes the Development of Pulmonary Hypertension Through the Sp1 (Specificity Protein 1)/SHMT2 (Serine Hydroxymethyltransferase 2) Pathway Hypertension. 2022 May;79(5):960-973._x000D_ 6: Katoh M, Katoh M. WNT signaling pathway and stem cell signaling network Clin Cancer Res. 2007 Jul 15;13(14):4042-5._x000D_ 7: Tai N, Inoue D. [Anti-Dickkopf1 (Dkk1) antibody as a bone anabolic agent for the treatment of osteoporosis] Clin Calcium. 2014 Jan;24(1):75-83._x000D_ 8: Rakipovski G, Rolin B, Barascuk N, Lund HE, Bjørn Bonde MF, Djordjevic D, Wulff-Larsen PG, Petersen M, Kirk RK, Hultman K, Manfe V, Blume N, Zahn S, Lengquist M, Maegdefessel L, Hovingh GK, Conde-Knape K, Hedin U, Matic L, Nyberg M. A neutralizing antibody against DKK1 does not reduce plaque formation in classical murine models of atherosclerosis: Is the therapeutic potential lost in translation? Atherosclerosis. 2020 Dec;314:1-9._x000D_ 9: Choi RB, Hoggatt AM, Horan DJ, Rogers EZ, Hong JM, Robling AG. Targeting Sclerostin and Dkk1 at Optimized Proportions of Low-Dose Antibody Achieves Similar Skeletal Benefits to Higher-Dose Sclerostin Targeting in the Mature Adult and Aged Skeleton Aging Dis. 2022 Dec 1;13(6):1891-1900._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/29845410">10: Morse A, Cheng TL, Schindeler A, McDonald MM, Mohanty ST, Kneissel M, Kramer I, Little DG. Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume Calcif Tissue Int. 2018 Sep;103(3):298-310. </a>_x000D_ _x000D_ <strong>Products Related to Rabbit DKK1 Antibody can be found at</strong> <a href="https://moleculardepot.com/product-category/Antibodies/"> Antibodies</a>