Wnt/β-catenin-IN-3

Wnt/β-catenin-IN-3 (compound 17) is a Wnt/β-catenin inhibitor with low micromolarGI50s against various cancer cells. Wnt/β-catenin-IN-3triggers G2/M cell cycle arrest though activation of p53-p21 pathway as well as intrinsic and extrinsic apoptotic death of colon cancer cells[1].

Product Specifications

CAS Number

[1809413-98-6]

UNSPSC

12352005

Target

MDM-2/p53; Wnt; β-catenin

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/wnt-β-catenin-in-3.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(C=C1)C(NC2=CC(C3=CC(C4=C(C(OC)=C(C=C4O3)OC)OC)=O)=CC=C2)=O

Molecular Formula

C26H23NO7

Molecular Weight

461.46

References & Citations

[1]Hassan AHE, et al. Discovery of a stilbenoid-flavanone hybrid as an antitumor Wnt/β-catenin signaling pathway inhibitor. Bioorg Chem. 2024 Apr;145:107178.