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Moxidectin (Standard)

Moxidectin (Standard) is the analytical standard of Moxidectin. This product is intended for research and analytical applications. Moxidectin (CL301423) is an orally active macrolide (ML) anthelmintic for the prevention and control of heartworms and roundworms. Moxidectin is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite mediated by Bcrp1 and P-gp. This may be related to the presence of chemical residues in milk[1][2][3].

Product Specifications

CAS Number

113507-06-5

Product Name Alternative

CL301423 (Standard)

UNSPSC

12352005

Hazard Statement

H301-H400

Target

Antibiotic; BCRP; Parasite; P-glycoprotein; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/moxidectin-standard.html

Solubility

H2O : < 0.1 mg/mL

Smiles

C/C([C@H]([C@H](/C1=N/OC)C)O[C@]2(C1)C[C@](OC([C@@](C=C(C)[C@@H](O)[C@@]3([H])OC/C4=C\C=C\[C@H](C)C5)([H])[C@@]34O)=O)([H])C[C@](C/C=C5\C)([H])O2)=C\C(C)C

Molecular Formula

C37H53NO8

Molecular Weight

639.82

Precautions

P264-P270-P273-P330-P391-P405-P501

References & Citations

[1]Moxidectin, From Wikipedia|[2]Kiki-Mvouaka S, et al. Role of P-glycoprotein in the disposition of macrocyclic lactones: A comparison between ivermectin, eprinomectin, and moxidectin in mice. Drug Metab Dispos. 2010 Apr;38 (4) :573-80.|[3]Perez M, et al. In vitro and in vivo interaction of moxidectin with BCRP/ABCG2. Chem Biol Interact. 2009 Jun 15;180 (1) :106-12.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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