Diquafosol
Diquafosol (INS365 free base) is a potent P2Y2 agonist. Diquafosol nhibits apoptosis and decreases ROS generation. Diquafosol has the potential for the research of dry eye[1].
Product Specifications
CAS Number
59985-21-6
Product Name Alternative
INS365 (free base)
UNSPSC
12352005
Target
Apoptosis; P2Y Receptor; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/diquafosol.html
Smiles
O[C@H]1[C@@H](O)[C@H](N(C(N2)=O)C=CC2=O)O[C@@H]1COP(O)(OP(OP(OP(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C(NC(C=C4)=O)=O)O3)(O)=O)(O)=O)(O)=O)=O
Molecular Formula
C18H26N4O23P4
Molecular Weight
790.31
References & Citations
[1]Park JH, et al. Diquafosol Sodium Inhibits Apoptosis and Inflammation of Corneal Epithelial Cells Via Activation of Erk1/2 and RSK: In Vitro and In Vivo Dry Eye Model. Invest Ophthalmol Vis Sci. 2018 Oct 1;59 (12) :5108-5115.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
P2Y2 Receptor
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