KB-0742
KB-0742 is a potent, selective and orally active CDK9 inhibitor with an IC50 of 6 nM for CDK9/cyclin T1. KB-0742 is selective for CDK9/cyclin T1 with >50-fold selectivity over other CDK kinases. KB-0742 has potent anti-tumor activity[1][2].
Product Specifications
CAS Number
[2416873-83-9]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kb-0742.html
Concentration
10mM
Purity
99.38
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
N[C@@H]1C[C@@H](NC2=CC(C(CC)CC)=NC3=CC=NN23)CC1
Molecular Formula
C16H25N5
Molecular Weight
287.40
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CDK1; CDK2; CDK3; CDK4; CDK5; CDK6; CDK7; CDK8; CDK9
Citation 01
University of California, Irvine. 2024.|bioRxiv. 2025 Nov 3:2025.11.02.685764.|Cell Chem Biol. 2025 Apr 17;32 (4) :542-555.e10.
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
FABP3, NT (Fatty Acid-binding Protein, Heart, Heart-type Fatty Acid-binding Protein, H-FABP, Fatty Acid-binding Protein 3, Muscle Fatty Acid-binding Protein, M-FABP, Mammary-derived Growth Inhibitor, MDGI, FABP11) (Biotin)
FABP3, NT (Fatty Acid-binding Protein, Heart, Heart-type Fatty Acid-binding Protein, H-FABP, Fatty Acid-binding Protein 3, Muscle Fatty Acid-binding Protein, M-FABP, Mammary-derived Growth Inhibitor, MDGI, FABP11) (Biotin)
Amino terminal enhancer of split (AES) (NM_001130) Human Over-expression Lysate