SU-4313
SU-4313 is a potent protein tyrosine kinases (PTKs) modulator with IC50s of 14.5 μM, 18.8 μM, 11 μM, 16.9 μM, 8.0 μM for PDGFR, FLK-1, EGFR, HER2 Kinase and IGF-1R, respectively. SU-4313 has the potential for modulating tyrosine kinase signal transduction in order to regulate abnormal cell proliferation[1].
Product Specifications
CAS Number
186611-55-2
UNSPSC
12352005
Hazard Statement
H315, H319
Target
EGFR; IGF-1R; PDGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/su-4313.html
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(/C1=C/C3=CC=C(C(C)C)C=C3)C=CC=C2
Molecular Formula
C18H17NO
Molecular Weight
263.33
Precautions
H315, H319
References & Citations
[1]Peng Cho Tang, et al. Indolinone compounds for the treatment of disease. WO1996040116A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2; PDGFR
Available Sizes
Frequently Asked Questions
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