MLEB-22043
MLEB-22043 is a synthetic siderophore-monobactam conjugate that is taken up into bacteria via its synthetic siderophore component by TonB-dependent transporters. Once inside the bacteria, it exerts antibacterial activity through its β-lactam component. MLEB-22043 is a broad-spectrum antibiotic with significant inhibitory activity against Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa[1].
Product Specifications
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mleb-22043.html
Smiles
NC1=NC(/C(C(N[C@]2([H])C(N(S(=O)(O)=O)[C@]2(C)[H])=O)=O)=N/OC(C)(C)C(NCC3=CN(CC(C(C=C(O)C(O)=C4)=C4O5)=CC5=O)N=N3)=O)=CS1
Molecular Formula
C26H27N9O11S2
Molecular Weight
705.68
References & Citations
[1]Weber BS, et al. High-Throughput Discovery of Synthetic Siderophores for Trojan Horse Antibiotics. ACS Infect Dis. 2024 Nov 8;10 (11) :3821-3841.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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