XE991 dihydrochloride

XE991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively[1].

Product Specifications

CAS Number

[122955-13-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/xe991-dihydrochloride.html

Concentration

10mM

Purity

99.63

Solubility

DMSO : 7.14 mg/mL (ultrasonic) |H2O : 11.11 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15.Cl.Cl

Molecular Formula

C26H22Cl2N2O

Molecular Weight

449.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang HS, et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282 (5395) :1890-3.|[2]Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis (4-pyridinylmethyl) -9 (10H) -anthracenone and 10,10-bis (2-fluoro-4-pyridinylmethyl) -9 (10H) -anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285 (2) :724-30.|[3]Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis (4-pyridinylmethyl) -9 (10H) -anthracenone and 10,10-bis (2-fluoro-4-pyridinylmethyl) -9 (10H) -anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285 (2) :724-30. PMID: 9580619.. . .