Men 10376 (TFA)

Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor[1].

Product Specifications

Product Name Alternative

Neurokinin-2 receptor antagonist (TFA)

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Men_10376_TFA.html

Purity

99.67

Solubility

H2O : 1.43 mg/mL (ultrasonic)

Smiles

OC(C(F)(F)F)=O.NCCCC[C@@H](C(N)=O)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](NC([C@H](C(C)C)NC([C@H](NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC3=CC=C(O)C=C3)=O)CC4=CNC5=C4C=CC=C5)=O)=O)CC6=CNC7=C6C=CC=C7)=O)=O

Molecular Formula

C59H69F3N12O12

Molecular Weight

1195.25

References & Citations

[1]Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51 (25) :1929-36.|[2]Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257 (3) :1172-8.