(3R,4S) -Tofacitinib

(3R,4S) -Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC50 of 1 nM.

Product Specifications

CAS Number

[1092578-46-5]

UNSPSC

12352005

Hazard Statement

H302-H360

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/_3R,4S_-Tofacitinib.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(C1=NC=NC2=C1C=CN2)[C@@H]3[C@@H](C)CCN(C(CC#N)=O)C3

Molecular Formula

C16H20N6O

Molecular Weight

312.37

Precautions

P264-P270-P280-P330-P405-P501

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

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