(3R,4S) -Tofacitinib
(3R,4S) -Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC50 of 1 nM.
Product Specifications
CAS Number
[1092578-46-5]
UNSPSC
12352005
Hazard Statement
H302-H360
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/_3R,4S_-Tofacitinib.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(C1=NC=NC2=C1C=CN2)[C@@H]3[C@@H](C)CCN(C(CC#N)=O)C3
Molecular Formula
C16H20N6O
Molecular Weight
312.37
Precautions
P264-P270-P280-P330-P405-P501
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7039400-01 0.02 mg
Recombinant Pseudomonas syringae pv. syringae UPF0060 membrane protein Psyr_3752 (Psyr_3752)
Sign In for Pricing
View Details 
MBS7039400-02 0.1 mg
Recombinant Pseudomonas syringae pv. syringae UPF0060 membrane protein Psyr_3752 (Psyr_3752)
Sign In for Pricing
View Details MBS7039400-03 5x 0.1 mg
Recombinant Pseudomonas syringae pv. syringae UPF0060 membrane protein Psyr_3752 (Psyr_3752)
Sign In for Pricing
View Details 
133875-ML490 100 µL
SSSCA1 (Sjoegren Syndrome/scleroderma Autoantigen 1, Autoantigen p27) (MaxLight 490)
Sign In for Pricing
View Details K4053708 1.0 µg DNA
Ppa2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
Sign In for Pricing
View Details