Purified Anti-Human ADAM10 Antibody[11G2]

ADAM10 (also known as Kuzbanian, mammalian disintegrin metalloprotease, myelin-associated metalloproteinase) is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain . Like other membrane-anchored ADAMs, ADAM10 consists of the following domains, pro with a cysteine switch and furin cleavage sequence, catalytic with the zinc-binding site and Met-turn expected for reprolysins, disintegrin-like, cysteine-rich, EGF-like, transmembrane, and cytoplasmic. ADAM10 is highly conserved, with 97% amino acid identity between mouse, rat, bovine and human and 45% identity between mouse and Drosophila. The active enzyme processes notch, notch ligand delta, and amyloid protein precursor at the alpha site, playing an important role in neurogenesis . It also processes the 26 kDa membrane-anchored pro-tumor necrosis factor-alpha (TNF-alpha) to the 17 kDa mature TNF-alpha. It cleaves myelin basic protein and type IV collagen. ADAM10 is widely expressed in tissues and resides both on the cell surface and in the cell.

CDw; ADAM; ADAM metallopeptidase domain; a disintegrin and metalloprotease domain; a disintegrin and metalloproteinase domain; disintegrin and metalloproteinase domain-containing protein; ADAM10; AD10; AD18; CD156c; CDw156; HsT18717; MADM; RAK; kuz; Kuzbanian; a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase domain 10; ADAM metallopeptidase domain 10; CD156c antigen; disintegrin and metalloproteinase domain-containing protein 10; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; ADAM metallopeptidase domain 10; CD156c; CDw156; HsT18717; kuz; MADM; AD 10; ADA10; ADAM 10; CD 156c; disintegrin and metalloproteinase domain containing protein 10; Drosophila; homolog of; HsT 18717; Mammalian disintegrin metalloprotease