BCPA
BCPA is a Pin1 regulator without cytotoxicity. BCPA attenuates the reduction of Pin1 protein to inhibit receptor activator of RANKL-induced osteoclastogenesis. BCPA regulates osteoclast activation, used to osteoporosis research[1].
Product Specifications
CAS Number
547731-67-9
UNSPSC
12352005
Target
PIN1
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bcpa.html
Purity
98.51
Solubility
DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(NCCCCNC(/C=C/C1=C(Cl)C=CC=C1)=O)/C=C/C2=C(Cl)C=CC=C2
Molecular Formula
C22H22Cl2N2O2
Molecular Weight
417.33
References & Citations
[1]Cho E, et al. BCPA {N, N′-1, 4-Butanediylbis [3- (2-chlorophenyl) acrylamide]} Inhibits osteoclast differentiation through increased retention of peptidyl-prolyl cis-trans isomerase never in mitosis A-interacting 1[J]. International Journal of Molecular Sciences, 2018, 19 (11) : 3436.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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