(1R,9R) -Exatecan (mesylate)
(1R,9R) -Exatecan mesylate ((1R,9R) -DX8951f) is an isomer of Exatecan mesylate. Exatecan mesylate (DX8951f) is an inhibitor of DNA topoisomerase I with an IC50 of 2.2 μM (0.975 μg/mL) and can be used in cancer research[1].
Product Specifications
CAS Number
2938875-39-7
Product Name Alternative
(1R,9R) -DX8951f
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1r-9r-exatecan-mesylate.html
Purity
99.94
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=S(C)(O)=O.O=C1[C@@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O
Molecular Formula
C25H26FN3O7S
Molecular Weight
531.55
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Camptothecins
Available Sizes
Frequently Asked Questions
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