ICRT3
ICRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription.
Product Specifications
CAS Number
[901751-47-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H318, H335, H413
Target
Apoptosis; Wnt
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/iCRT3.html
Purity
99.55
Solubility
DMSO : 150 mg/mL (ultrasonic; warming)
Smiles
O=C(NCCC1=CC=CC=C1)CSCC2=C(C)OC(C3=CC=C(CC)C=C3)=N2
Molecular Formula
C23H26N2O2S
Molecular Weight
394.53
Precautions
H302, H315, H318, H335, H413
References & Citations
[1]Xiao H, et al. A Novel Positive Feedback Loop Between NTSR1 and Wnt/β-Catenin Contributes to Tumor Growth of Glioblastoma. Cell Physiol Biochem. 2017 Oct 24;43 (5) :2133-2142.|[2]Chatterjee SS, et al. Inhibition of β-catenin-TCF1 interaction delays differentiation of mouse embryonic stem cells. J Cell Biol. 2015 Oct 12;211 (1) :39-51.|[3]Sharma A, et al. Mitigation of sepsis-induced inflammatory responses and organ injury through targeting Wnt/β-catenin signaling. doi: 10.1038/s41598-017-08711-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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