Venlafaxine-d6 (hydrochloride)

Venlafaxine-d6 (hydrochloride) is the deuterium labeled Venlafaxine hydrochloride. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT) /norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1].

Product Specifications

CAS Number

[1062606-12-5]

Product Name Alternative

Wy 45030-d6 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H410

Target

Serotonin Transporter

Type

Isotope-Labeled Compounds

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Purity

98.18

Solubility

DMSO : 10mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1(C(C2=CC=C(OC)C=C2)CN(C([2H])([2H])[2H])C([2H])([2H])[2H])CCCCC1.[H]Cl

Molecular Formula

C17H22D6ClNO2

Molecular Weight

319.90

Precautions

H410

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Bymaster FP, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25 (6) :871-80.|[3]Goeringer KE, et al. Postmortem tissue concentrations of venlafaxine. Forensic Sci Int. 2001 Sep 15;121 (1-2) :70-5.