Retinoic acid-d5

Retinoic acid-d5 is the the deuterium labeled Retinoic acid (HY-14649) . Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2][3][4][5].

Product Specifications

CAS Number

[78996-15-3]

Product Name Alternative

Vitamin A acid-d5; all-trans-Retinoic acid-d5; ATRA-d5

UNSPSC

12352211

Hazard Statement

H302, H315, H360, H410

Target

Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; PPAR; RAR/RXR

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.25

Solubility

10 mM in DMSO|DMSO : 50mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)/C=C(C)/C=C/C=C(C)/C=C/C1=C(C([2H])([2H])[2H])C([2H])([2H])CCC1(C)C

Molecular Formula

C20H23D5O2

Molecular Weight

305.47

Precautions

H302, H315, H360, H410

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[3]Wu L, et al. Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis. PLoS One. 2016 Apr 14;11 (4) :e0153556.|[4]Shaw N, et al. Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor beta/delta. J Biol Chem. 2003 Oct 24;278 (43) :41589-92.|[5]Yu S, et al. Retinoic acid induces neurogenesis by activating both retinoic acid receptors (RARs) and peroxisomeproliferator-activated receptor β/δ (PPARβ/δ) . J Biol Chem. 2012 Dec 7;287 (50) :42195-205.