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Dacomitinib (hydrate)

Dacomitinib (PF-00299804) hydrate is an orally active, irreversible pan-ErbB inhibitor. Dacomitinib hydrate can be used in the research of cancers such as metastatic non-small cell lung cancer (NSCLC) [1].

Product Specifications

CAS Number

1042385-75-0

Product Name Alternative

PF-00299804 (hydrate) ; PF-299804 (hydrate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dacomitinib-hydrate.html

Purity

99.54

Solubility

DMF : 10 mg/mL (ultrasonic)

Smiles

O=C(/C=C/CN1CCCCC1)NC2=CC3=C(C=C2OC)N=CN=C3NC4=CC=C(C(Cl)=C4)F.O

Molecular Formula

C24H27ClFN5O3

Molecular Weight

487.95

Precautions

H302, H315, H319, H335

References & Citations

[1]Lau SCM, et al. Dacomitinib in the Management of Advanced Non-Small-Cell Lung Cancer. Drugs. 2019 Jun;79 (8) :823-831.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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