Dimethyl-SGD-1882

Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication[1].

Product Specifications

CAS Number

[3026416-27-0]

Product Name Alternative

Dimethyl-PBD dimer

UNSPSC

12352203

Target

ADC Payload

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dimethyl-sgd-1882.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12N(C(C3=CC(OC)=C(OCCCOC4=C(C=C5C(N=C[C@]6(C)N(C=C(C7=CC=C(OC)C=C7)C6)C5=O)=C4)OC)C=C3N=C2)=O)C=C(C8=CC=C(N)C=C8)C1

Molecular Formula

C44H43N5O7

Molecular Weight

753.84

References & Citations

[1]Mantaj J, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD) -Containing Antibody-Drug Conjugates (ADCs) . Angew Chem Int Ed Engl. 2017 Jan 9;56 (2) :462-488.