BRAF inhibitor
BRAF inhibitor (Compound P-0850) is a B-Raf inhibitor with anti-tumor activity[1][2].
Product Specifications
CAS Number
918505-61-0
UNSPSC
12352005
Hazard Statement
H302, H317
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BRAF-inhibitor.html
Purity
99.22
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)S(=O)(NC1=CC=C(C(C(C2=CNC3=NC=C(C=C32)C4=CC=CN=C4)=O)=C1F)F)=O
Molecular Formula
C22H18F2N4O3S
Molecular Weight
456.47
Precautions
H302, H317
References & Citations
[1]Prahbha N. Ibrahim, et al. Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors. WO2007002325A1.|[2]Zhang C, et al. Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibition. Cell Death Dis. 2022 Jul 15;13 (7) :615.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf
Available Sizes
Frequently Asked Questions
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