BRAF inhibitor

BRAF inhibitor (Compound P-0850) is a B-Raf inhibitor with anti-tumor activity[1][2].

Product Specifications

CAS Number

[918505-61-0]

UNSPSC

12352005

Hazard Statement

H302, H317

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BRAF-inhibitor.html

Purity

99.22

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)S(=O)(NC1=CC=C(C(C(C2=CNC3=NC=C(C=C32)C4=CC=CN=C4)=O)=C1F)F)=O

Molecular Formula

C22H18F2N4O3S

Molecular Weight

456.47

Precautions

H302, H317

References & Citations

[1]Prahbha N. Ibrahim, et al. Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors. WO2007002325A1.|[2]Zhang C, et al. Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibition. Cell Death Dis. 2022 Jul 15;13 (7) :615.