22- (tert-Butoxy) -22-oxodocosanoic acid

22- (tert-Butoxy) -22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . 22- (tert-Butoxy) -22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t

Product Specifications

CAS Number

[1642333-05-8]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/22-tert-butoxy-22-oxodocosanoic-acid.html

Purity

99.24

Solubility

10 mM in DMSO

Smiles

O=C(OC(C)(C)C)CCCCCCCCCCCCCCCCCCCCC(O)=O

Molecular Formula

C26H50O4

Molecular Weight

426.67

Precautions

H302, H315, H319, H335

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.