UDP-Galactose (disodium)

UDP-Galactose disodium is a natural agonist of the P2Y14 receptor with an EC50 of 0.67 μM for the hP2Y14 receptor. UDP-Galactose disodium is a substrate for the transferase beta-1, 4 galactosyltransferase V (B4GALT5) . In addition, UDP-Galactose disodium is required for the biosynthesis of several abundant glycoconjugates that form the surface glycocalyx of Leishmania major[1][2][3].

Product Specifications

CAS Number

[137868-52-1]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; P2Y Receptor

Type

Biochemical Assay Reagents

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/udp-galactose-disodium.html

Purity

99.73

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@@H]3[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)(O[Na])=O)(O[Na])=O)O2)NC1=O

Molecular Formula

C15H22N2Na2O17P2

Molecular Weight

610.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Ko H, et al. Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. J Med Chem. 2007 May 3;50 (9) :2030-9.|[2]Drabavicius G, Daelemans D. Intermedilysin cytolytic activity depends on heparan sulfates and membrane composition. PLoS Genet. 2021 Feb 12;17 (2) :e1009387.|[3]Lamerz A C, et al. Deletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania major[J]. Glycobiology, 2010, 20 (7) : 872-882.|[4]Norambuena L, et al. Transport of UDP-galactose in plants. Identification and functional characterization of AtUTr1, an Arabidopsis thaliana UDP-galactos/UDP-glucose transporter. J Biol Chem. 2002 Sep 6;277 (36) :32923-9.|[5]Broussard A, et al. Human UDP-galactose 4'-epimerase (GALE) is required for cell-surface glycome structure and function. J Biol Chem. 2020 Jan 31;295 (5) :1225-1239.