NIBR189

NIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC50s of 11 and 16 nM, respectively. NIBR189 can be used for the research of autoimmune diseases[1].

Product Specifications

CAS Number

[1599432-08-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

EBI2/GPR183; EBV

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/NIBR189.html

Purity

99.71

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1CCN(C(C2=CC=C(OC)C=C2)=O)CC1)/C=C/C3=CC=C(Br)C=C3

Molecular Formula

C21H21BrN2O3

Molecular Weight

429.31

Precautions

H315, H319, H335

References & Citations

[1]Gessier F, et al. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J Med Chem. 2014 Apr 24;57 (8) :3358-68.