NIBR189
NIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC50s of 11 and 16 nM, respectively. NIBR189 can be used for the research of autoimmune diseases[1].
Product Specifications
CAS Number
[1599432-08-2]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
EBI2/GPR183; EBV
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/NIBR189.html
Purity
99.71
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N1CCN(C(C2=CC=C(OC)C=C2)=O)CC1)/C=C/C3=CC=C(Br)C=C3
Molecular Formula
C21H21BrN2O3
Molecular Weight
429.31
Precautions
H315, H319, H335
References & Citations
[1]Gessier F, et al. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J Med Chem. 2014 Apr 24;57 (8) :3358-68.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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