A 1070722

A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain. A 1070722 decreases spontaneous locomotion[1][2].

Product Specifications

CAS Number

[1384424-80-9]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/a-1070722.html

Purity

99.87

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

FC(F)(F)C1=NC(NC(NC2=CC=NC3=C2C=CC(OC)=C3)=O)=CC=C1

Molecular Formula

C17H13F3N4O2

Molecular Weight

362.31

Precautions

H301, H315, H319, H335

References & Citations

[1]Prabhakaran J, et al. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 Aug 16;8 (8) :1697-1703.|[2]Rocca J F. Effect of glycogen synthase kinase-3 inhibition on the acquisition and expression of cocaine-cue conditioned activity and spontaneous locomotion in rodents. Queen's University (Canada), 2014.