DCLX069
DCLX069 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 value of 17.9 µM. DCLX069 shows less active against PRMT4 and PRMT6. DCLX069 has anticancer effects[1].
Product Specifications
CAS Number
[792946-69-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dclx069.html
Concentration
10mM
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C(N)=C1)N2CCN(CC2)CC3=CC=CC=C3)OCC
Molecular Formula
C20H25N3O2
Molecular Weight
339.43
Precautions
H302, H315, H319
References & Citations
[1]Yiqian Xie, et al. Virtual screening and biological evaluation of novel small molecular inhibitors against protein arginine methyltransferase 1 (PRMT1) . Org Biomol Chem. 2014 Dec 21;12 (47) :9665-73.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT1
Available Sizes
Curated Selection
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