N-Boc-dolaproine
N-Boc-dolaproine ((2R,3R) -BOC-dolaproine) is the amino acid residue of the pentapeptide Dolastatin 10. Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].
Product Specifications
CAS Number
120205-50-7
Product Name Alternative
(2R,3R) -BOC-dolaproine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Microtubule/Tubulin; Mitosis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-boc-dolaproine.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CO[C@H]([C@@H](C)C(O)=O)[C@H]1N(C(OC(C)(C)C)=O)CCC1
Molecular Formula
C14H25NO5
Molecular Weight
287.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Almeida W P, et al. An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis–Hillman reaction[J]. Tetrahedron letters, 2003, 44 (5) : 937-940.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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