N-Boc-dolaproine

N-Boc-dolaproine ((2R,3R) -BOC-dolaproine) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580) . Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].

Product Specifications

CAS Number

[120205-50-7]

Product Name Alternative

(2R,3R) -BOC-dolaproine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Microtubule/Tubulin; Mitosis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-boc-dolaproine.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CO[C@H]([C@@H](C)C(O)=O)[C@H]1N(C(OC(C)(C)C)=O)CCC1

Molecular Formula

C14H25NO5

Molecular Weight

287.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Almeida W P, et al. An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis–Hillman reaction[J]. Tetrahedron letters, 2003, 44 (5) : 937-940.