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Nylidrin (hydrochloride)

Nylidrin hydrochloride (Buphenine hydrochloride) is an orally active β-adrenergic agonist. Nylidrin hydrochloride antagonizes NR1A/2B NMDA receptors (IC50 = 0.18 μM in Xenopus oocytes) . Nylidrin hydrochloride reduces the levels of NP, HA, and M1. Nylidrin hydrochloride has antiviral activity against multiple H1N1 subtype influenza A viruses. Nylidrin hydrochloride improves hemorrhagic shock and anti-allergic effects[1][2][3][4][5].

Product Specifications

CAS Number

849-55-8

Product Name Alternative

Buphenine hydrochloride

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

IGluR; Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Nylidrin-hydrochloride.html

Purity

98.66

Solubility

DMSO : ≥ 41 mg/mL|H2O : 5 mg/mL (ultrasonic)

Smiles

OC(C(NC(C)CCC1=CC=CC=C1)C)C2=CC=C(O)C=C2.[H]Cl

Molecular Formula

C19H26ClNO2

Molecular Weight

335.87

Precautions

H302, H312, H332

References & Citations

[1]A Khandwala, et al. Antiallergic activity of nylidrin hydrochloride (RHC 3432-A) . I. Effect on release of histamine in vitro from rat peritoneal mast cells, guinea pig lung slices and human basophils. International Archives of Allergy & Applied Immunology, 1983, 70 (4) |[2]Boiteau GM, et al. Nylidrin HCl: a beta-sympathetic stimulant in the management of haemorrhagic shock. Can Anaesth Soc J. 1966 May;13 (3) :252-62.|[3]Niemeyer G, et al. Effects of buphenine (nylidrin) on the perfused mammalian eye. Graefes Arch Clin Exp Ophthalmol. 1987;225 (1) :33-8.|[4]Whittemore ER, et al. Subtype-selective antagonism of NMDA receptors by nylidrin. Eur J Pharmacol. 1997 Oct 22;337 (2-3) :197-208.|[5]Jang Y, et al. In Vitro and In Vivo Antiviral Activity of Nylidrin by Targeting the Hemagglutinin 2-Mediated Membrane Fusion of Influenza A Virus. Viruses. 2020 May 25;12 (5) :581.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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