EBV lytic cycle inducer-1

Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin (HY-15149) and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers[1][2].

Product Specifications

CAS Number

[394668-43-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EBV

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ebv-lytic-cycle-inducer-1.html

Purity

98.27

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC(Br)=CC=C1)N/N=C(C)/C2=NC=CC=C2

Molecular Formula

C14H12BrN3O

Molecular Weight

318.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Chung King Choi, et al. Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies. PLoS One. 2015 Dec 30;10 (12) :e0145994.|[2]Stephanie Pei Tung Yiu, et al. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers Cancers 2018 Dec; 10 (12) : 505.