Imexon
Imexon (BM 06002) is an iminopyrrolidone aziridine with anti-cancer activity.
Product Specifications
CAS Number
59643-91-3
Product Name Alternative
BM 06002
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Imexon.html
Purity
99.79
Solubility
DMSO : 62.5 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N2CC2C(N)=N1
Molecular Formula
C4H5N3O
Molecular Weight
111.10
Precautions
H315, H319
References & Citations
[1]Sheveleva EV, et al. Imexon induces an oxidative endoplasmic reticulum stress response in pancreatic cancer cells. Mol Cancer Res. 2012 Mar;10 (3) :392-400.|[2]Samulitis BK, et al. Interaction of dacarbazine and imexon, in vitro and in vivo, in human A375 melanoma cells. Anticancer Res. 2011 Sep;31 (9) :2781-5.|[3]Roman NO, et al. Imexon enhances gemcitabine cytotoxicity by inhibition of ribonucleotide reductase. Cancer Chemother Pharmacol. 2011 Jan;67 (1) :183-92.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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