Imexon

Imexon (BM 06002) is an iminopyrrolidone aziridine with anti-cancer activity.

Product Specifications

CAS Number

[59643-91-3]

Product Name Alternative

BM 06002

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Imexon.html

Purity

99.79

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N2CC2C(N)=N1

Molecular Formula

C4H5N3O

Molecular Weight

111.10

Precautions

H315, H319

References & Citations

[1]Sheveleva EV, et al. Imexon induces an oxidative endoplasmic reticulum stress response in pancreatic cancer cells. Mol Cancer Res. 2012 Mar;10 (3) :392-400.|[2]Samulitis BK, et al. Interaction of dacarbazine and imexon, in vitro and in vivo, in human A375 melanoma cells. Anticancer Res. 2011 Sep;31 (9) :2781-5.|[3]Roman NO, et al. Imexon enhances gemcitabine cytotoxicity by inhibition of ribonucleotide reductase. Cancer Chemother Pharmacol. 2011 Jan;67 (1) :183-92.