FLNC rabbit pAb

This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

Q14315

Swiss Prot

Q14315

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human FLNC AA range: 335-385

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF

Concentration

1 mg/ml

Dilution

IHC-p 1: 50-200

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cytoplasm . Membrane ; Peripheral membrane protein . Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme. Targeting to developing and mature Z lines is mediated by the intradomain insert.