Florfenicol amine (hydrochloride)

Florfenicol amine hydrochloride is a metabolite of Florfenicol (HY-B1374) . Florfenicol inhibits bacterial protein synthesis by binding to 50S and 70S subunits in the ribosome to abolish the activity of peptidyltransferase. Florfenicol, is a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases[1][2].

Product Specifications

CAS Number

[108656-33-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Drug Metabolite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/florfenicol-amine-hydrochloride.html

Concentration

10mM

Purity

98.61

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CS(C1=CC=C(C=C1)[C@H]([C@@H](CF)N)O)(=O)=O.Cl

Molecular Formula

C10H15ClFNO3S

Molecular Weight

283.75

Precautions

H302, H315, H319, H335

References & Citations

[1]B-K Park, et al. Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus) . J Vet Pharmacol Ther. 2006 Feb;29 (1) :37-40.|[2]Anadón A, et al. Plasma and tissue depletion of florfenicol and florfenicol-amine in chickens. J Agric Food Chem. 2008 Nov 26;56 (22) :11049-56.