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Ibuprofen-d3 (sodium)

Ibuprofen-d3 ((±) -Ibuprofen-d3) sodium is the deuterium labeled Ibuprofen sodium (HY-78131C) . Ibuprofen sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][3][4].

Product Specifications

CAS Number

[1219805-09-0]

Product Name Alternative

(±) -Ibuprofen-d3 (sodium)

UNSPSC

12352005

Target

Apoptosis; COX; Isotope-Labeled Compounds; Parasite

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Others

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Purity

99.0

Solubility

10 mM in DMSO|DMF : ≥ 30mg/mL|DMSO : ≥ 50mg/mL|Ethanol : ≥ 50mg/mL

Smiles

O=C(O[Na])C(C([2H])([2H])[2H])C1=CC=C(CC(C)C)C=C1

Molecular Formula

C13H14D3NaO2

Molecular Weight

231.28

References & Citations

[1]Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61 (1) :2-7. |[2]Hassan Akrami, et al. Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell. Tumour Biol. 2015 May;36 (5) :3237-43. |[3]Nathan D Pennock, et al. Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. J Immunother Cancer. 2018 Oct 1;6 (1) :98. |[4]M W Konstan, et al. Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection. Implications for antiinflammatory therapy in cystic fibrosis. Am Rev Respir Dis. 1990 Jan;141 (1) :186-92.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-78131CS/Ibuprofen-d3-sodium-SDS-MedChemExpress.pdf

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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