TRPM7-IN-1
TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. TRPM7-IN-1 induces cell cycle arrest and apoptosis, decreases the migration of MCF-7 and BGC-823 cells. TRPM7-IN-1 decreases vimentin expression and increases E-cadherin expression. TRPM7-IN-1 potentially reduces the TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway. TRPM7-IN-1 is a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function[1].
Product Specifications
CAS Number
1909225-07-5
UNSPSC
12352211
Target
Akt; Apoptosis; PI3K; TRP Channel
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trpm7-in-1.html
Purity
98.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC(C1=CC=CC=C1N(C)C)=O)NC2=CC=C(OC3=NC(C)=CC(C)=N3)C(C)=C2
Molecular Formula
C23H25N5O3
Molecular Weight
419.48
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt; PI3K; TRPM7
Available Sizes
Frequently Asked Questions
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