TRPM7-IN-1

TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. TRPM7-IN-1 induces cell cycle arrest and apoptosis, decreases the migration of MCF-7 and BGC-823 cells. TRPM7-IN-1 decreases vimentin expression and increases E-cadherin expression. TRPM7-IN-1 potentially reduces the TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway. TRPM7-IN-1 is a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function[1].

Product Specifications

CAS Number

[1909225-07-5]

UNSPSC

12352211

Target

Akt; Apoptosis; PI3K; TRP Channel

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/trpm7-in-1.html

Purity

98.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC(C1=CC=CC=C1N(C)C)=O)NC2=CC=C(OC3=NC(C)=CC(C)=N3)C(C)=C2

Molecular Formula

C23H25N5O3

Molecular Weight

419.48

References & Citations

[1]Xiaoding Zhang, et al. Novel benzoylurea derivative decreases TRPM7 channel function and inhibits cancer cells migration. Channels (Austin) . 2024 Dec;18 (1) :2396339.