WRN inhibitor 10
WRN inhibitor 10 (Compound P24) is an inhibitor for the Werner helicase WRN with an IC50 of 1.1 nM. WRN inhibitor 10 inhibits the proliferation of cancer cell SW48 with IC50 of 39 nM. WRN inhibitor 10 exhibits good liver microsomal stability and film permeability. WRN inhibitor 10 exhibits good pharmacokinetic characteristics in CD-1 mice[1].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wrn-inhibitor-10.html
Smiles
O=C(N1CCN(CC1)C2=C(N(C3=NC(C4=CC5=C(S4)COC5)=NN3C2=O)CC(NC6=CC=C(C=C6Cl)Br)=O)CC)C7=NC=NC(C)=C7O
Molecular Formula
C31H29BrClN9O5S
Molecular Weight
755.04
References & Citations
[1]Liu B, et al., WRN inhibitors. CN118271323A.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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