S1RA
S1RA (E-52862) is a highly selective σ1 receptor (σ1R) antagonist with Kis of 17 nM and 23.5 nM for human σ1R and guinea pig σ1R, respectively. S1RA has Moderate antagonistic activity for human 5-HT2B receptor (Ki= 328 nM). S1RA has antinociceptive effects in neuropathic pain models. S1RA prevents mechanical and cold hypersensitivity in Oxaliplatin -treated mice[1][2].
Product Specifications
CAS Number
878141-96-9
Product Name Alternative
E-52862
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
5-HT Receptor; Sigma Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s1ra.html
Concentration
10mM
Purity
99.43
Solubility
1M HCl : 50 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CC(OCCN2CCOCC2)=NN1C3=CC(C=CC=C4)=C4C=C3
Molecular Formula
C20H23N3O2
Molecular Weight
337.42
Precautions
H302, H315, H320, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT2 Receptor; Sigma 1 Receptor; Sigma 2 Receptor; α-1 microglobulin
Available Sizes
Frequently Asked Questions
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