HBA (111–142)

HBA (111-142), an antimicrobial peptide, is a C-terminal 32-mer fragment of alpha-hemoglobin. HBA (111-142) has antibacterial activity against the ESKAPE panel of pathogens. HBA (111-142) forms amyloid fibrils, and has antiviral activities. HBA (111-142) inhibits measles and herpes viruses (HSV-1, HSV-2, HCMV) [1].

Product Specifications

UNSPSC

12352209

Target

Bacterial; CMV; HSV

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hba-111-142.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](C)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC(C)C)C(N2[C@@H](CCC2)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H]([C@H](O)C)C(N4[C@@H](CCC4)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Molecular Formula

C157H247N41O45

Molecular Weight

3428.89

References & Citations

[1]Olari LR, et al. The C-terminal 32-mer fragment of hemoglobin alpha is an amyloidogenic peptide with antimicrobial properties. Cell Mol Life Sci. 2023 May 17;80 (6) :151.