MY-875
MY-875 is a competitive microtubulin polymerization inhibitor with an IC50 value of 0.92 μM. MY-875 inhibits microtubulin polymerization by targeting colchicine binding sites and activates the Hippo pathway. MY-875 induces apoptosis and has anticancer activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/my-875.html
Concentration
10mM
Purity
99.56
Solubility
DMSO : ≥ 250 mg/mL
Smiles
COC1=CC(N(C(/C=C/C)=O)CC2=CC(O)=C(OC)C=C2)=CC(OC)=C1OC
Molecular Formula
C21H25NO6
Molecular Weight
387.43
References & Citations
[1]Jian Song, et al. Discovery of N-benzylarylamide derivatives as novel tubulin polymerization inhibitors capable of activating the Hippo pathway. Eur J Med Chem. 2022 Jul 7;240:114583.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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