Lactic acid (potassium)

Lactic acid (DL-Lactic acid) potassium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid potassium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid potassium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2]. Lactic acid also potassium has antimicrobial activity, which can be used as a food preservative[3].

Product Specifications

CAS Number

[996-31-6]

Product Name Alternative

DL-Lactic acid (potassium) ; E-270 (potassium)

UNSPSC

12352300

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Endogenous Metabolite; Hydroxycarboxylic Acid Receptor (HCAR)

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lactate-potassium.html

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

OC(C([O-])=O)C.[K+]

Molecular Formula

C3H5KO3

Molecular Weight

128.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24 (1) :24.|[2]Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13 (1) :4981. |[3]Sallam KI. Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon. Food Control. 2007 May;18 (5) :566-575.