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Phloracetophenone

Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2].

Product Specifications

CAS Number

480-66-0

Product Name Alternative

2,4,6-trihydroxyacetophenone; 1- (2,4,6-Trihydroxyphenyl) ethanone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; Cytochrome P450

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Phloracetophenone.html

Purity

99.98

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)

Smiles

CC(=O)C1=C(O)C=C(O)C=C1O

Molecular Formula

C8H8O4

Molecular Weight

168.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Charoenteeraboon J, et al. Induction of human cholesterol 7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone. Eur J Pharmacol. 2005 May 16;515 (1-3) :43-6.|[2]Piyachaturawat P, et al. Choleretic activity of phloracetophenone in rats: structure-function studies using acetophenone analogues. Eur J Pharmacol. 2000 Jan 10;387 (2) :221-7.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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