U-74389G

U-74389G (PNU74389G meleate) is an antioxidant, can inhibit lipid peroxidation reactions. U-74389G can protect against ischemia-reperfusion injury and be widely used in animal models of ischemic injury and hypertension. U-74389G shows anti-inflammatory activity[1][2][3].

Product Specifications

CAS Number

[153190-29-5]

Product Name Alternative

PNU74389G (meleate)

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Others; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/u-74389g.html

Purity

98.64

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(/C=C\C(O)=O)=O.C[C@@]12[C@](CC[C@@H]2C(CN3CCN(C4=NC(N5CCCC5)=NC(N6CCCC6)=C4)CC3)=O)([H])[C@@]7([H])C([C@@]8(C(CC7)=CC(C=C8)=O)C)=CC1

Molecular Formula

C41H54N6O6

Molecular Weight

726.90

References & Citations

[1]A M Perna, et al. Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G. Pharmacol Res. 1996 Jul-Aug;34 (1-2) :25-31.|[2]Georgios Antonios Margonis, et al. Effectiveness of sildenafil and U-74389G in a rat model of colitis. J Surg Res. 2015 Feb;193 (2) :667-74.|[3]D Altavilla, et al. The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock. Eur J Pharmacol. 1999 Mar 12;369 (1) :49-55.