(Rac) -Bepotastine (besilate)

(Rac) -Bepotastine (besilate) is the isomer of Bepotastine (besilate) (HY-A0015), and can be used as an experimental control. Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF) . Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research[1][2][3][4].

Product Specifications

CAS Number

[1415692-17-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rac-bepotastine-besilate.html

Purity

99.52

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=CC=C1)(O)=O.O=C(CCCN2CCC(CC2)OC(C3=NC=CC=C3)C4=CC=C(C=C4)Cl)O

Molecular Formula

C27H31ClN2O6S

Molecular Weight

547.06

Precautions

H302, H315, H319, H335

References & Citations

[1]Kida T, et al. Bepotastine besilate, a highly selective histamine H (1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. Exp Eye Res. 2010 Jul;91 (1) :85-91.|[2]Kamata Y, et al. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 2018 Apr 23:S0923-1811 (18) 30186-5.|[3]Tanizaki H, et al. Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. Int Arch Allergy Immunol. 2008;145 (4) :277-82.|[4]Jon I Williams, et al. Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Curr Med Res Opin. 2010 Oct;26 (10) :2329-38.