YAP/TAZ inhibitor-2
YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity[1].
Product Specifications
CAS Number
2762617-31-0
UNSPSC
12352005
Hazard Statement
H315, H319
Target
YAP
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yap-taz-inhibitor-2.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=C(F)C(N1CC(N2N=C(C3=CC=C(C(F)(F)F)C=C3)C4=CC=CN=C42)C1)=O
Molecular Formula
C19H14F4N4O
Molecular Weight
390.33
Precautions
H315, H319
References & Citations
[1]Xu, xiaofeng, et al. Bicyclic compounds, compositions and use thereof. WO2022037568A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
YAP/TAZ-TEAD
Available Sizes
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